According to the Centers for Disease Control and Prevention, C-difficile kills 15,000 people each year mostly seniors and is currently the most common microbial cause of health care-associated infections in U.S. hospitals, costing up to $4.8 billion annually. [30], Trehalose is an ingredient, along with hyaluronic acid, in an artificial tears product used to treat dry eye. Given that most people have trehalase in the gut, these tiny creatures have probably been our staple food throughout evolution [59, 60, 54]. Through Prof. Wilcoxs research and presentation at the Trehalose Symposium, it is clear that trehalose is not associated with the rise in epidemic strains of C. diff. https://doi.org/10.1016/j.ebiom.2019.04.038, Trehalose-Induced Remodelling of the Human Microbiota Affects, Is there a causal relationship between trehalose consumption and, Microbial and metabolic impacts of trehalose and trehalose analogues, Genetic determinants of trehalose utilization are not associated with severe, Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting, Degradation-Resistant Trehalose Analogues Block Utilization of Trehalose by Hypervirulent, Dietary trehalose enhances virulence of epidemic. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Except where otherwise noted, data are given for materials in their standard state (at 25 C [77 F], 100 kPa). ?) Trehalose (from Turkish ' tgala ' a sugar derived from insect cocoons + -ose) is a sugar consisting of two molecules of glucose. Tests on 20 volunteers confirmed that trehalose causes a milder increase in blood glucose (38%) and insulin (36%), compared with an equal amount of glucose [40]. The Nature paper is not a single study, but rather a compilation of summaries of individual experiments each conducted by one or more of the authors listed on the paper. These strains thrived on trehalose and produced much more toxins [52, 53]. Online ahead of print. Trehalose Food
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